RETRACTED:The Results Observation on Adjuvant Chemotherapy with Microwave Hyperthermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage) Lung Cancer

doi:10.4236/jcc.2016.43012

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Title of retracted article: The Results Observation on Adjuvant Chemotherapy with Microwave

Hyperthermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage)

Lung Cancer

Author(s): Xihao Yu1, Xinping Li1, Guiyun Dong1, Wenyan Yu2, Jianping Wang1, Ying Xiong

DOI (to PDF):

* Corresponding author. Email:[email protected]

Journal: Journal of Computer and Communications(JCC)

Year: 2016

Volume: 4

Number: 3

Pages (from - to): 79 - 82

10.4236/jcc.2016.43012

Paper ID at SCIRP: 64147

Article page: http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=64147

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Journal of Computer and Communications, 2016, 4, 79-82

Published Online Ma rch 2016 in SciRes. http://www.scirp.org/journal/jcc

http://dx.doi.org/10.4236/jcc.2016.43012

How to cite this paper: Yu , X.H., et al. (2016) The Results Observation on Adjuvant Chemotherapy with Microwave Hyper-

thermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage) Lung Cancer. Journal of

Computer and Communications, 4, 79-82. http://dx.doi.org/10.4236/jcc.2016.43012

The Results Observation on Adjuvant

Chemotherapy with Microwave

Hyperthermia and Stereotactic

Radiotherapy in Retreated Elderly

Patients with Advanced

(III/IV Stage) Lung Cancer

Xihao Yu1, Xinping Li1, Guiyun Dong1, Wenyan Yu2, Jianping Wang1, Ying Xiong1

1Department of Oncology of Liberation Army 85 Hospital, Shanghai, China

2Basic Medical College of Shanghai Jiaotong University, Shanghai, China

Received 14 January 2016; accepted 26 February 2016; published 2 March 2016

Abstract

Objective: To evaluate the significance of adjuvant chemotherapy and radiotherapy (Gamma-knife)

in the elderly patients with retreated advance lung cancer. Methods 83 patients (age 50 to 81

years) with retreating advanced (III/IV stage) lung cancer were divided into three groups accord-

ing to patients received treating by different methods. The cases were treated by synchronous

chemo-radiotherapy (A group), sequentially chemo-radiotherapy (B group) and continuous sys-

tematized chemotherapy alone (C group). The systemic 3-dimensional orientation apparatus was

used in radiotherapy. The chemotherapy regimen in combined radiotherapy was given by com-

mon first line regimen on lung cancer. The regimen of chemotherapy combated with whole body

hyperthermia by using micro-wave on abodeman about 2 or 3 line was used in C group only. Re-

sults: The overall responses rates (RR) of A, B and C groups were 17.1%, 11.5% and 31.8%, but it

was non-significance difference (P > 0.05). Overall responses rates (RR) of III and IV stage groups

were 18.2% and 20.0%. The average overall survival time (OS) and median survival time (MST) of

the patients treated by chemotherapy (C group) were highest about 14.2 and 9.3 months (respec-

tively at A group 6.7 and 6.0 months. P < 0.01), in which B group was longer than A group (P <

0.05), and 95.5% CI value was not overlap. The total survival time of postoperative patients was

longer in the various groups by different treated than that in non-operations. Conclusion: The

rates (RR) of III and IV stage groups were non-significance difference. The higher of ORR, OS and

MST in a few patients of re-treated advanced lung cancer was presented in case with treated by

continuous system chemotherapy. There were survival superiority in initial postoperative pa-

tients groups by different treated. It is a profitable and effect treatment that the pure reasonable

systemic chemotherapy was used for elderly case with advanced retreated lung cancer.

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X. H. Yu et al.

Keywords

Elderly Patients, Chemotherapy, Combined Radiotherapy, Lung Cancer

1. Background

The retreating to elder patients with advanced lung cancer is a problems that often needs to be faced in clinical

practice. A number of studies have shown that appropriately chemotherapy or radiotherapy is better than the best

supportive care. Due to the special physiological function of old patients, it was considered that how to choose

the best treatment for the patients. Especially for patients treated again, at present this kind of research is not

much. It is object about the paper to investigate the effect and significance of adjuvant chemotherapy with

hyperthermia and radiotherapy (Gamma-knife) in the treatment of elderly patients with retreated advance lung

cancer.

2. Clinical Material and Methods

Eighty-three patients, median age 67.3 year (50 to 81 years), with retreating advanced (III/IV stage) lung cancer

were divided into three groups according to patients received treating by different methods. 35 cases were

treated by synchronous chemo-radiotherapy (group A). 26 cases were treated by sequentially chemo-radiothe-

rapy (group B) and 22 cases were treated by continuous systematized chemotherapy alone (group C). (see Table

1). All patients were selected for inclusion in study after the initial treatment stoped 2 - 3 months. The systemic

3-dimensional orientation apparatus was used in radiotherapy. The total dose of 35-55GY was given in syn-

chronous or sequential chemo-radiotherapy. The chemotherapy regimen in combined radiotherapy was given by

common first line regimen on lung cancer. (NSCLC: NVB25 mg/m2 d1, 8, GEM 0 .8 - 1.0/m2 d1, 8, DDP 40 mg

d1-3 or D DP 20 mg d1-5. SCLC: CBP AUC = 5, VP16 0.1/m2. q21d). The part chemotherapy combated with

whole body hyperthermia by using micr o-wave on abodeman in temperature 40˚C - 42˚C for 1 - 2 hours. The

regimen of chemotherapy about 2 or 3 line was used in C group only. Drugs was used at Taxol (Squibb US, Co)

175 mg/ m2 d1, or Docertacel (Aventis Pharma, SA, Co) 70 - 80 mg/m2, d1; Pemetrexed (Lilly France SAS, Co)

500 mg/m2, d1.). The responce rate was statistically based on RECIST (WHO) method.

Statistical analysis The categorical variables percent date were compared between the two groups by using the

inpendent X2 test. Continuous data were compared between two groups by using independent t test. A two-tailed

P value of < 0.05 was considered statistically significant. Survival was calculated by using the Kaplan-Meier

method and compared by using the log-rank test. The Kaplan-meier curve was used to exhibit survival time.

3. Results

1) The overall responses rates (RR) of A, B and C groups were 17.1%, 11.5% and 31.8%, but it was non-sig-

nificance difference respectively at three group (P > 0.05). The higher effective rate was presented in stage III

case with synchronous chemo-radiotherapy (23.1%), and in stage IV with continuous systematized chemothera-

py alone (38.5%), but overall responses rates (RR) of III/IV stage groups was non-significance difference (18.2%

and 20.0%) (see Table 2).

2) The average overall survival time (OS) and median survival time (MST) of the patients treated by chemo-

Table 1. The general state of the patients with cancer on different treating groups.

Groups Cases SEX Mid-age Stage (%) PS (%)

M F III IV ≤2 ≥3

group A 35 23 12 54.6 13 (37.1) 22 (62.8)* 25 (71.4) 10 (28.6*)

group B 26 20 6 51.2 11 (42.3) 15 (57.7) 16 (61.5) 10 (38.5)

group C 22 13 9 56.5 9 (40.9) 14 (63.7)* 14 (63.7) 8 (36.3)

*P > 0.05.

RETRACTED

X. H. Yu et al.

therapy (C group) were highest about 14.2 and 9.3 months (respectively at A group 6.7 and 6.0 months. P <

0.01), in which B group was longer than A group (P < 0.05), and 95.5% CI value was not overlap. The Kap-

lan-meier curve for survival time was showed (shown in Figu re 1).

3) The total survival time of initial postoperative patients were longer in the various groups by different

treated than that in non-operations (see Table 3).

Table 2. The contrast about respond rate (RR) in different treating groups.

Group Stage III Stage IV RR (%)

N RR (%) N RR (%)

Syn.che-rad (A) 13 3 (23.1) 22 3 (13.6)# 6/35 (17.1)

Seq.che-rad (B) 11 1 (9.1) 15 2 (13.3) 3/26 (11.5)

Chem.onl (C) 9 2 (22.2) 13 5 (38.5)+ 7/22 (31.8)*

33 6 (18.2) 50 10 (20.0) 16/83 (19.3)

*X2 = 1.87. P > 0.05 (contrast between C and B); +X2 = 2.86. P > 0.05 (contrast between C and A); #X2 = 0.51 P > 0.05 (contrast between stage IV and

III in A group).

Table 3. Survival time (months) on different treating groups with post-operation.

Content No operation Post-operation

MST n

MST

Syn.che-rad (A) 30 6.5 5.0 5 19.2 13.4

Seq.che-rad (B) 20 9.9 7.0 6 17.0 15.0

65 9.1 7.0 16 20.5 14.5*

*t = 2.79. P < 0.01 (post-ope.cont no ope. about MST).

Figure 1. The Kaplan-meier survival rate of different treating groups. 一●: group A, 一■: group B, 一▲:group C.

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X. H. Yu et al.

4. Discussion

Stereotactic gamma knife radiotherapy for intracranial tumor and somatic localized tumors can make small part

of radical effect to the operation as a knife. However, chemotherapy is often needed for patient with recurrence

and metastasis [1]. However studies have indicated that, after radiotherapy or early chemotherapy, the residual

tumorcells can accelerate the proliferation, which make the tumor more difficult to control [2]. So it is very im-

portant to follow up the system chemotherapy or consolidation chemotherapy. Hyperthermia can increase the ef-

ficacy of chemotherapy and reduce side effect, in which it can appropriately reduce the dose of chemotherapy

drug and more suitable for the elderly. Although surgical treatment of lung cancer, especially in the initial

treatment still occupies an important position [3], our research also shows that there were survival superiority in

initial postoperative patients groups by subsequent different treated. But it is not possible for the elderly tumor

patients to choose again. This clinical observation study of this paper suggested that the synchronous chemo-

radiotherapy can partly increased about RR of the patients with stage I II case, and higher effective rate was pre-

sented in stage IV with continuous systematized chemotherapy, but the rates (RR) of III and IV stage groups

were non-significance difference. The higher of ORR, OS and MST in a few patients of re-treated advanced

lung cancer was presented in case with treated by continuous system chemotherapy. Conclusion: It is a profita-

ble and effect treatment that the pure reasonable systemic chemotherapy was used for elderly case with ad-

vanced retreated lung cancer.

References

[1] Lin, J.-C., Jan , J.-S., Hsu, C.-Y., et al. (2003) Phase 3 Study of Concurrent Chemoradiotherapy versus Radiotherapy

Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival. Journal of

Clinical O ncolog y, 21, 631-637. http://dx.doi.org/10.1200/JCO.2003.06.158

[2] Mehta, M., Scrimger, R., Mackkie, R., et al. (2001) A New Approach to Dose Escalation in Non-Small-Cell Lung

Cancer. International Journal of Radiation Oncology Bio logy Physics, 49, 23-33.

http://dx.doi.org/10.1016/S0360-3016(00)01374-2

[3] Nagai, K., Sohara, Y., Tsachiya, R., et al. (2007) Prognosis of Resectd Non-Small Cell Lung Cancer Patients with

Intrapalmonary Metastases. Journal of Thoracic Oncology, 2, 282-286.

http://dx.doi.org/10.1097/01.JTO.0000263709.15955.8a

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