Advances in Biosynthetic Pathways
Biosynthesis, i.e., chemical synthesis occurring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products. Examples of biosynthetic pathways include those for the production of amino acids, lipid membrane components, and nucleotides, but also for the production of all classes of biological macromolecules, and of acetyl-coenzyme A, adenosine triphosphate, nicotinamide adenine dinucleotide and other key intermediate and transactional molecules needed for metabolism. Thus, in biosynthesis, any of an array of compounds, from simple to complex, are converted into other compounds, and so it includes both the catabolism and anabolism (building up and breaking down) of complex molecules (including macromolecules). Biosynthetic processes are often represented via charts of metabolic pathways. A particular biosynthetic pathway may be located within a single cellular organelle (e.g., mitochondrial fatty acid synthesis pathways), while others involve enzymes that are located across an array of cellular organelles and structures (e.g., the biosynthesis of glycosylated cell surface proteins).
In the present book, eleven typical literatures about biosynthetic pathways published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on biosynthetic pathways. We hope this book can demonstrate advances in biosynthetic pathways as well as give references to the researchers, students and other related people.
Sample Chapter(s)
Preface (177 KB)
Components of the Book:
  • Chapter 1
    A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes
  • Chapter 2
    Crystal structures and low-affinity complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway
  • Chapter 3
    A hybrid biosynthetic-catabolic pathway for norspermidine production
  • Chapter 4
    Xanthones: Biosynthesis and Trafficking in Plants, Fungi and Lichens
  • Chapter 5
    Expanding the repertoire of imine reductases by mining divergent biosynthetic pathways for promiscuous reactivity
  • Chapter 6
    Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways
  • Chapter 7
    The riboflavin biosynthetic pathway as a novel target for antifungal drugs against Candida species
  • Chapter 8
    Genetic Characterization of the Acidic and Neutral Glycosphingolipid Biosynthetic Pathways in Neurospora crassa
  • Chapter 9
    Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex
  • Chapter 1
    Two Novel Iboga-Type and an Oxindole Glucuronide Alkaloid from Tabernaemontana peduncularis Disclose Related Biosynthetic Pathways to Tabernaemontana divaricata
  • Chapter 11
    Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes
Readership: Students, academics, teachers and other people attending or interested in biosynthetic pathways.
Niraj Mehta
Department of Chemistry, Stanford University, Stanford, CA 94305, USA

Margaret A. Phillips
UT Southwestern Medical School, Dallas, United States

Camilla Badiali
Department of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy

and more...
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