Advances in Phage Therapy
Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War. Bacteriophages, known as phages, are a form of virus that attach to bacterial cells and inject their genome into the cell. The bacteria's production of the viral genome interferes with its ability to function, halting the bacterial infection. The bacterial cell causing the infection is unable to reproduce and instead produces additional phages. Phages are very selective in the strains of bacteria they are effective against.
In the present book, ten typical literatures about Phage Therapy on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on Phage Therapy. We hope this book can demonstrate advances in Phage Therapy as well as give references to the researchers, students and other related people.
Sample Chapter(s)
Preface (87 KB)
Components of the Book:
  • Chapter 1
    Phage therapy: An alternative to antibiotics in the age of multi-drug resistance
  • Chapter 2
    Real-time monitoring by interferometric light microscopy of phage suspensions for personalised phage therapy
  • Chapter 3
    Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection
  • Chapter 4
    Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection
  • Chapter 5
    Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University
  • Chapter 6
    Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumonia
  • Chapter 7
    An enterococcal phage protein inhibits type IV restriction enzymes involved in antiphage defense
  • Chapter 8
    Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler
  • Chapter 9
    A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections
  • Chapter 10
    Targeting Pseudomonas aeruginosa biofilm with an evolutionary trained bacteriophage cocktail exploiting phage resistance trade-offs
Readership: Students, academics, teachers and other people attending or interested in Phage Therapy.
Britt Koskella
Derek M Lin, Henry C Lin, Section of Gastroenterology, New Mexico VA Health Care System, Albuquerque, NM 87108, United States

Benjamine Lapras
Pharmacy Department, Hospices Civils de Lyon, Hôpital E. Herriot, Plateforme FRIPHARM, 69437, Lyon, France

Fabian Kunisch
Faculty of Medicine, Universität Münster, Münster, Germany

and more...
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