Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease.
Components of the Book:
- Chapter 1
Requirement of the transcription factor YB-
1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells
- Chapter 2
Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis
- Chapter 3
An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia
- Chapter 4
ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population
- Chapter 5
Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition
- Chapter 6
Cancer cell reprogramming to identify the
genes competent for generating liver cancer stem cells
- Chapter 7
LncRNA BCAR4, targeting to miR‑665/STAT3
signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal
cancer
- Chapter 8
Development of a therapy against
metastatic bladder cancer using an interleukin-2 surface-modified MB49 bladder cancer stem cells vaccine
- Chapter 9
Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer
- Chapter 1O
Mesenchymal stem cells promote glioma
neovascularization in vivo by fusing with cancer stem cells
- Chapter 11
STAT3, stem cells, cancer stem cells and p63
- Chapter 12
Small putative NANOG, SOX2, and SSEA-4-
positive stem cells resembling very small embryonic-like stem cells in sections of ovarian tissue in patients with ovarian cancer
- Chapter 13
Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs
- Chapter 14
Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness
- Chapter 15
Elevated level of mitochondrial reactive
oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition
Readership:
Students, academics, teachers and other people attending or interested in Cancer Stem Cells
Zonghui Ding
Zonghui Ding, Department of Biochemistry and Molecular Biology, Mayo Clinic, Arizona, USA
Max S. Wicha
Max S. Wicha, Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Aleksander S. Popel
Aleksander S. Popel, Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, USA
Travis Wallace
Travis Wallace, Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, USA
Hui Chen
Hui Chen, Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xiaoying He
Xiaoying He, Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
and more...