Advances in Telomerase

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of eukaryotic chromosomes in most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres.

Components of the Book:
  • Chapter 1
    Epigenetic analysis of high and low motile sperm populations reveals methylation variation in satellite regions within the pericentromeric position and in genes functionally related to sperm DNA organization and maintenance in Bos Taurus
  • Chapter 2
    Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways
  • Chapter 3
    Angiogenesis and immune checkpoint inhibitors as therapies for hepatocellular carcinoma: current knowledge and future research directions
  • Chapter 4
    Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche
  • Chapter 5
    A Phase Ib/II, open‑label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma
  • Chapter 6
    Pilot experience of multidisciplinary team discussion dedicated to inherited pulmonary fibrosis
  • Chapter 7
    The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-ofexpression anaplastic astrocytomas
  • Chapter 8
    Markers of pancreatic cancer stem cells and their clinical and therapeutic implications
  • Chapter 9
    Impact of continuous predator threat on telomere dynamics in parent and nestling pied flycatchers
  • Chapter 10
    HPV-associated cancers
  • Chapter 11
    The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
  • Chapter 12
    Xenobiotica‑metabolizing enzymes in the lung of experimental animals, man and in human lung models
  • Chapter 13
    Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage
  • Chapter 14
    Sex‑specific effects of the in ovo environment on early‑life phenotypes in eiders
  • Chapter 15
    The nucleolus: a central response hub for the stressors that drive cancer progression
Readership: Students, academics, teachers and other people attending or interested in Telomerase
Julien Calderaro, Department of Pathology, Henri Mondor Hospital, Créteil, France; IMRB-INSERM U955 Team 18, Créteil, France

Rachel J. Waddington, School of Dentistry, Cardiff Institute of Tissue Engineering and Repair (CITER), College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK

Patrick Y. Wen, Center for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA

Ghazaleh Tabatabai, Interdisciplinary Division of Neuro-Oncology, Center for CNS Tumors, Comprehensive Cancer Center, University Hospital Tübingen, Hertie Institute for Clinical Brain Research & Eberhard Karls University Tübingen, German Cancer Consortium (DKTK),DKFZ Partner Site TübingenTübingen, Germany

Fernando Navarro-Mateu, Unidad de Docencia, Investigación y Formación en Salud Mental (UDIF-SM), Servicio Murciano de Salud, Murcia, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIB-Arrixaca Murcia Spain; Departamento de Psicología Básica y Metodología, University of Murcia, Murcia, Spain

Robert Landsiedel, Experimental Toxicology and Ecology, Ludwigshafen, Germany

and more...
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