Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitors in the treatment of cancer. Cancer cells are cells that have lost their ability to divide in a controlled fashion. A malignant tumor consists of a population of rapidly dividing and growing cancer cells that progressively accrues mutations. However, tumors need a dedicated blood supply to provide the oxygen and other essential nutrients they require in order to grow beyond a certain size. The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as “hot and bloody.”

In the present book, fifteen typical literatures about tumor angiogenesis published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, angiology, oncology, epidemiology, ect. We hope this book can demonstrate advances in tumor angiogenesis as well as give references to the researchers, students and other related people.